GENOTYPE-SYMPTOMATOLOGY CORRELATION STUDIES IN PATIENTS WITH ANXIETY

Projects: To explore the relationship of lncRNAs with altered expression in peripheral blood with symptomatogy in anxiety patients. Methods: Gene microarray was carried on to screen the lncRNAs with altered expressions between anxiety patients (GAD) and healthy people (NC), and qPCR was performed to validate these screened lncRNAs. GAD was assessed by HAMA to analyze differently-expressed lncRNAs and its relationship with symptomatology. Results: 1. The expression levels of PR1-PR10 were positively relayed to psychic anxiety and the total score of HAMA (r=0.187~0.253，P 0.01 or P 0.05), the expression level of PR7 was positively related to somatic anxiety (r=0.171，P 0.05); 2. ROC curve combined analysis showed that the AUC value of ten lncRNAs arrived at 0.808, at chic YI=YImax, sensitivity and specificity was 66.3%, 90.5% respectively; 3. High expression group of PR7 (NONHSAG049179) was significantly higher than that in low expression group accounting for psychic anxiety, aromatic anxiety and total score of HAMA. Conclusion: lncRNA with altered expression may be involved in MDD, and NONHSAG049179 is closely associated with psychic anxiety and somatic anxiety.