Compare cognitive functions of prefrontal cortex in OCD patients, obsessive beliefs group, and healthy group

Introduction: Brain imaging studies have shown reduced activity in the frontal lobe in OCD patients. The aim of this study is compare functions of dorso-lateral prefrontal cortex and orbitofrontal cortex in OCD patients, obsessive beliefs group, and healthy group. Method: 21 college student with OCD, 21 college student with obsessive beliefs, and 22 normal college student were chosen by Madzeli obsessive- compulsive questionnaire, and OBQ-44 test. WCST and CPT tasks was performed on all subjects in 3 groups. Results: The data analysis showed that there were significant differences between OCD group, obsessive beliefs group, and healthy group in CPT variables(omission and commission error). There were not significant differences between OCD group, Obsessive Beliefs group, and healthy group in WCST variable(perseveration error). Conclusions: Obsessive-compulsive patients show deficits in orbitofrontal function, while this deficits have not seen in Obsessive Beliefs group and healthy group.