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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.05, No. 04)

Publication Date:

Authors : ;

Page : 2316-2325

Keywords : Oral fast dissolving film; cinnarizine; motion sickness; menier’s disease; HPMC E5; PEG 400; solvent casting;

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Cinnarizine is a H1 anti-histaminic drug and it can be used in the treatment of nausea, vomiting, motion sickness, vertigo and in menier's disease. The purpose of present work was a development of fast dissolving oral film of cinnarizine, to overcome the limitation of current routes of administration to provide faster dissolution rate and increase the patient compliance. The amount of dose of drug calculate according to the area covered by the 15ml formulation without drug. The amount of drug was then used for the preparation of film by using solvent casting method utilizing HPMC E5 as a film forming polymer and PEG 400 as a plasticizer. The 32 factorial design was applied for optimization of concentration of polymer HPMC E5 and plasticizer PEG 400. The prepared film were evaluated for various parameters like film thickness, folding endurance, drug content, dispersion test, uniformity of weight, surface pH measurement, moisture loss study, in vitro drug dissolution study, disintegration time and stability vitro drug dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer).among all the formulation, formulation (F5) which contain HPMC E5 (15%)and PEG400( 6%) were released upto 98.17% of the drug from the film within 25 sec. which exhibit faster absorption and also shows desirable characteristics of film than other formulation. Keywords: Oral fast dissolving film, cinnarizine, motion sickness, menier's disease, HPMC E5, PEG 400, solvent casting

Last modified: 2018-04-15 02:58:02