ROLE OF SIMVASTATIN IN ADDITION TO METFORMIN IN POLYCYSTIC OVARIAN SYNDROME PATIENTS, A RANDOMIZED CONTROLLED TRIAL ON PAKISTANI WOMEN

Objective: To study the effect of using simvastatin in addition to metformin in treatment of polycystic ovarian syndrome (PCOS) and its comparison with metformin alone therapy. Methods: This is a randomized controlled trial conducted at Pakistan Institute of Medical Sciences (PIMS), during November 2014 to April 2015. Total 108 patients were enrolled in study and were stratified into two groups, consisting of 54 each. First group was given metformin alone while second group was given metformin and simvastatin. An extensive clinical history, menstrual history was taken from all participants and data was recorded on a pre-designed proforma. Complete clinical examination was performed on all patients. Abdominopelvic ultrasound was performed and volume >10cc or >12 follicles was labelled as enlarged. Lipid profile and LH/FSH ratio was performed at the time of enrollment and was repeated after 3 months to see response to treatment. The effective treatment response was more than 15% decrease in baseline values in comparison to data found at the time of enrollment. Results: 28.87.18 years was the mean age. The mean BMI was 22.5 1.55 kg/m2 . The effective results were achieved in 66.7% patients in metformin alone group while in 92.6% patients in combination therapy group. Conclusion: Simvastatin and metformin combination therapy is better than metformin alone for treatment of polycystic ovarian syndrome. Keywords: Polycystic ovarian syndrome, females, metformin, simvastatin, lipid profile, LH/FSH ratio.