FREQUENCY OF HYPERSPLENISM IN CASES OF LIVER CIRRHOSIS

Objective: To determine the frequency of Hypersplenism in cases of liver cirrhosis. Methodology: This cross sectional study was conducted at Sheikh Zayed Hospital, Lahore during January to August 2017. The cases with liver cirrhosis were labelled according to clinical symptoms, deranged liver function tests and on Ultrasonography abdomen. The cases were included of both genders with age 20 years or more with child pugh class B and C. The cases with any hematological malignancy or end stage renal of cardiac failure were excluded. Hypersplenism was labelled on bone marrow examination with normal to hyper cellular marrow. Results: In the present study there were total 130 cases of liver cirrhosis. Out of these 84 (64.61%) were males and 46 (35.39%) females. The mean age was 53.45±8.23 years. Hypersplenism was observed in 65 (50%) of the cases. Hypersplenism was significantly high in male group seen in 51 (60.71%) cases with p= 0.01. There was near significant difference in terms of age groups where it was seen in 48 (56.47%) cases with age more than 50 years with p= 0.06. Hypersplenism was significantly high in cases with child pugh class C affecting 55 (56.70%) cases with p value of 0.02. Conclusion: Hypersplenism is not uncommon in liver cirrhosis and is seen significantly high in cases with child pugh class C and male gender. Key Words: Liver cirrhosis, Hypersplenism.