Prolactin and Reproductive Hormone Status in Women with Oligomenorrhea and Infertility Problem

Background: Oligomenorrhea is a common problem of women these days. Oligomenorrhea during reproductive age group may lead to infertility which may bring stress, social stigma, dispute between husband and wife. The present study was designed to assess the Prolactin, Follicular Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in oligomenorrheic patients in Eastern region of Nepal. Methods: A total of 126 patients came to the immunoassay laboratory of Department of Biochemistry for the testing of Prolactin, LH and FSH from Department of the Obstetrics and Gynecology with complain of oligomenorrhea, primary infertility and secondary infertility. These patients were enrolled in the study with informed consent. Blood samples were collected in plain vial. Serum Prolactin, FSH and LH were measured by ELISA method (Eliscan, India). Results: The mean age of patients was 24.33±5.91 which ranges from 15-45 years. Majority of them had complain of oligomenorrhea (76.2%) and other 23.8% of them had either primary or secondary infertility. In women with infertility, 53.33 % had elevated level of prolactin, 43.3% of women had decreased FSH and 46.6 % of women had decreased LH. In oligomenorrheic women, 41.66% women had elevated level of Prolactin, 51% women had decreased FSH and 56.2% women had decreased LH. There was no statistical difference between the median values of LH (p=0.961) and Prolactin (p=0.229) in oligomenorrhea and infertile group. Conclusion: Our study showed that there was no remarkable difference of serum LH and Prolactin between women with oligomenorrhea and infertile problem