Marchiafava Bignami Disease – Typical and Atypical Etiologies

Marchiafava Bignami Disease (MBD) is a rare toxic demyelinating neuroetiology conventionally associated with chronic alcoholism. It can also be seen in patients with chronic malnutrition. The presentation is with neurocognitive manifestations. Typical involvement of corpus callosum on MRI is what clinches the diagnosis. MRI with diffusion weighted imaging is imperative in early disease for timely intervention and prognostication. Lucid description of two cases is presented – with typical and atypical etiologies – followed by detailed discussion of the disorder