CORRECTIVE ACTION OF CERIUM DIOXIDE NANOPARTICLES IN THE CONDITIONS OF OXIDATIVE STRESS INPUT OF DOXORUBICIN-INDUCED CARDIOMYOPATHY IN RATS

Anthracycline antibiotics are used in oncology practice for the treatment of a wide range of malignant tumors. Doxorubicin is the most used and effective drug in this group. However, this antibiotic has a pronounced cardiotoxic effect and often leads to the development of dilated cardiomyopathy (DCM). It is believed that the cardiotoxic effect of doxorubicin is associated with the activation of free radical oxidation processes and the development of oxidative stress, therefore, the use of nanodispersed cerium dioxide (CeO2 ), which by its physical-chemical properties can act as a trap of highly reactive derivatives of oxygen (ROS) and nitrogen (RNS), is a promising approach in overcoming the negative side effects of doxorubicin therapy. The study showed that, against the background of experimental doxorubicin-induced cardiomyopathy in rats, the introduction of nanodispersed CeO2 improves the general condition of animals, restores the architectonics of cardiomyocytes, and also partially normalizes some biochemical parameters and indices of oxidative stress.