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The role of TLR4 in up-regulation of autophagy-related protein and MMP9, MMP14 expression via EMMPRIN stimulated THP-1 macrophages
Journal: Journal of Cardiovascular Medicine and Cardiology (Vol.6, No. 4)Publication Date: 2019-11-19
Authors : Zhiming Wang Changqing Zhao Yaxian Song Xing Liang Zhihua Yang Ruiwei Guo; Lixia Yang;
Page : 082-087
Keywords : TLR4; Extracellular matrix metalloproteinase inducer; Autophagy; Matrix metalloproteinases; Coronary heart disease;
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Abstract
This study investigated the mechanism of toll-like receptor 4(TLR4) in up-regulating autophagy-related protein and matrix metalloproteinase 9(MMP9), MMP14 expression in THP-1 macrophages which were stimulated by Extracellular Matrix Metalloproteinase Inducer (EMMPRIN). So that exploring its importance in the progression of Coronary Heart Disease (CHD).
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Last modified: 2019-12-24 20:59:17