Review on Strategies and Prospective of in Situ Nasal Gel

Nowdays many drugs have best systemic bioavailability through nasal route as compared to oral administration. In these intranasal drug delivery enables dose reduction and rapid attainment of therapeutics, bloods levels, quicker onsets of pharmacological activity, and fewer side effects. The recent advancement of nasal drug delivery system has increased tremendously and is gaining significant importance. The anatomy of nasal route, advantages, disadvantages, mechanism of action, limitation, factors affecting nasal delivery, applications and future trends of nasal drug delivery system in local delivery, systematic delivery, nasal vaccines and CNS delivery are lucidly. The important aspects of biological, physicochemical and pharmaceutical and pharmacological factors of nasal cavity that must be considered during the process of discovery as well as development of new drugs for nasal delivery as in corporation into appropriate different nasal pharmaceutical formulation are also discussed. Nasal route is more suitable for those drugs which cannot be administered orally due to more gastric degradation or hepatic first pass metabolism of the drug. Intra nasal delivery is non invasive technique, essentially painless, does not require sterile preparation, and is easily and readily administered by the patients or a physician, as in emergency setting. Further addition, intranasal drug delivery reduces dose size increase rapid nasal delivery of therapeutic blood levels, quicker onset of pharmacological activity, and fewer side effects. There are various approaches in nasal drug, delivering a therapeutic substance to the target site. Jyoti Lokhande | Smita More "Review on Strategies and Prospective of in Situ Nasal Gel" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31739.pdf Paper Url :https://www.ijtsrd.com/pharmacy/pharmaceutics/31739/review-on-strategies-and-prospective-of-in-situ-nasal-gel/jyoti-lokhande