ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Imatinib resistance in chronic myelogenous leukemia: an emerging challenge

Journal: International Journal of Basic & Clinical Pharmacology (Vol.3, No. 5)

Publication Date:

Authors : ; ; ; ;

Page : 908-911

Keywords : Chronic myeloid leukemia; Imatinib resistance; blast crisis;

Source : Downloadexternal Find it from : Google Scholarexternal


Resistance to imatinib is a significant clinical issue, and the underlying mechanism of this resistance is multifactorial. The efficacy of imatinib in chronic myeloid leukemia (CML) in achieving a high remission rate and improving prognosis has seriously been challenged by the development of mutants of BCR-ABL gene, which resist the action of imatinib, which is a tyrosine kinase inhibitor. We present here a case of a 35-year-old male, a known case of CML on imatinib therapy, the patient eventually landed in blast crisis and succumbed to the disease and secondary infections.

Last modified: 2014-10-25 16:50:48