Development of an Effective Disinfectant Based on Amine, Aldehyde and Chlorine-Containing Compounds

The use of compositions as disinfectants instead of individual substances has the advantage of being more effective. In this work, the disinfecting ability of 48 compositions, including triethanolamine, glutaraldehyde, sodium hypochlorite, and chlorine dioxide, was investigated. By the method of serial dilution for each composition,the value of the minimum inhibitory concentration (MIC) of microorganisms was determined. Using regression analysis, an equation for the dependence (function) of the MIC on the content of components in the composition was obtained. The composition that meets the minimum function contained, wt %: triethanolamine -11; glutaraldehyde -74; sodium hypochlorite -6; chlorine dioxide -9. The experimentally found value of the MIC for this composition was 1395 μg/L, which is significantly lower than the MIC of any component of the composition. This means a higher efficiency of the composition as a disinfectant in comparison with the individual components. This fact was explained by the synergistic effect.