Synthesis, Characterization and Cosmetic Application of (E)-3-(2-Hydoxyphenyl)-N (4-Nitrophenyl) Acrylamide, A Novel Compound by Using Green Chemistry Techniques

Amides collectively are defined as a class of pharmaceutically and medicinally important compounds. Very long reaction times, consumption of large quantities of organic solvents, presence of an acid catalyst etc make the synthesis of these compounds very tedious and costly. However, green chemistry techniques are gaining popularity recently, as they are relatively fast and also reduce chemical waste generation. We have employed green chemistry principles for the synthesis of Amide and described the method here. Natural jamun fruit juice freeze dry extract was used as natural acid catalyst for the synthesis of (E)-3-(2-Hydoxyphenyl)-N(4-Nitrophenyl) Acrylamide, from 2-Hydroxy cinnamic acid and 4-Nitroaniline and was characterized by FT-IR and NMR. Antioxidant skin efficacy of these products was tested on human subjects and promising effect was observed and reported. Thus, the stated green chemical approach for the synthesis of amides was stated to be convenient, affordable, simple, efficient, eco-friendly and cost-effective.