NOVEL FLOATING BILAYER DRUG DELIVERY SYSTEM-A REVIEW

Oral sustained release gastroretentive dosage forms offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach. Floating drug delivery system is one amongst the gastroretentive dosage forms used to achieve prolonged gastric residence time. Bilayer floating drug delivery system is combined principle of bilayer tablet as well as floating mechanism. Bilayer floating tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bilayer floating tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. The purpose of this paper is to review the current technology used in the development of bilayer floating drug delivery system as well as summarizes the applications, characterization, evaluation methods and future potential for bilayer floating tablets. KEYWORDS: Bilayer Floating Tablets, GRDDS