PROTECTIVE EFFECT OF OCIMUM SANCTUM ON GENTAMICIN INDUCED NEPHROTOXICITY RATS

The present study deals with nephrotoxicity in humans and we can use ocimum sanctum plants aqueous leaf extract as nephron protective in kidneys. The purpose of pharmaceuticals research is to develop new drugs. The present research work done on gentamicin induced nephrotoxicity rats by doing experimentation. Aminoglycoside antibiotics including gentamicin are widely used in the treatment of gram-negative infections. However the major complication of the use of these drugs is nephrotoxicity, accounting for 10-15% of all cases of acute renal failure. The nephrotoxicity of gentamicin is well established in man & experimental animals. Gentamicin induced nephrotoxicity was ameliorated by various mechanisms among which oxidant mechanism was chosen by us to proceed in experimentation. The experimentation follows by various steps in nephrotoxicity rats and by the plant’s leaves extract of ocimum sanctum is induced in rats and the resulting the disease can be controlled and various factors are shown by comparing creatinine levels and factors required to decrease the nephrotoxicity occurred by using antibiotics.