EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF CARICA PAPAYA SEEDS ON WISTAR RATS

The aim of the present study was to elucidate the role of methanolic extract of carica papaya seeds during hyperlipidemia induced by Triton X100 in rats and antherogenic diet rats (AD). Triton X100 and Antherogenic diet was used to induce acute hyperlipidemia. It is well known that triton X100 elevates the total TC and TG levels by altering the hepatic lipid metabolism. Hyperlipidemic rats treated with Atorvastatin, Lovastatin, low dose and high dose of carica papaya seeds (Methanol extract) showed a significant decrease of serum TG’s, cholesterol and significant increase of serum HDL-C levels compared to hyperlipidemia control. The potential of protective effect may be due to the rich source of polyphones present as a chief chemical constituent but the exact mechanism is still not clear. The findings of the present study revealed that carica papaya seedsin both low (100 mg/kg) and high (200 mg/kg) doses show anti-hyperlipidemic activity against Triton X-100 induced hyperlipidemia. Among all treated groups carica papaya seeds-200 mg/kg shown better protection. So, we can conclude that methanolic extract of Carica Papaya seeds treatment produced a marked anti hyperlipidemic activity when rats were acutely treated. In our study no lethality was observed atleast for the dose and duration used.