ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login


Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.5, No. 12)

Publication Date:

Authors : ; ; ; ;

Page : 11-22

Keywords : Solubility; BCS Classification; Solubility Enhancement Techniques; Solubility Enhancers;

Source : Downloadexternal Find it from : Google Scholarexternal


The solubility enhancement process of hydrophobic drugs is crucial in formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. About 40% of the new chemical entities that have been identified by pharmaceutical industry screening programs face numerous problems in the formulation and development stage due to the poor water solubility and low bioavailability. Drug solubility and bioavailability enhancement are the important challenges in the field of formulation of pharmaceuticals. The Bio pharmaceutics Classification System depicts that Class II and IV drugs have a low water solubility, poor dissolution, and low bioavailability. This review highlights on the importance, advantages, disadvantages, techniques of solubility enhancement.

Last modified: 2020-12-18 21:09:02