Analysis of Parachloroaniline Formation through Protocols of Associations between Irrigating Solutions During Chemical-Mechanical Preparation

The success of endodontic therapy depends on the biomechanical preparation and hermetic filling of root canals, but does not generate sufficient microbial reduction in most cases. Chlorhexidine has been used in endodontics due to the wide spectrum of action. However, associated with other irrigation solutions can form Parachloroaniline (PCA), a possible carcinogen for humans, according to the IARC (International Agency for Research on Cancer). The aim of this study is to analyze the formation of PCA through protocols that associate irrigation solutions in chemical-mechanical preparation. Fifty lower premolars teeth extracted from humans were selected, then separated into 5 groups (n=10) for 5 different irrigation protocols and at the end were microscopically analyzed. According to the results obtained only the irrigation protocol of group 5 had the formation of PCA in the three thirds of the root.