FORMULATION AND EVALUATION OF SLN BASED TOPICAL GEL OF KETOROLAC TROMETHAMINE

Ketorolac tromethamine is frequently non-steroidal anti-inflammatory drug (NSAIDs) with analgesic, anti-inflammatory and antipyretic properties, is also nice in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. Solid lipid nanoparticles (SLNs) are able to be used for the focused on of anti-inflammatory drugs, thus accomplish most significant advantages such as reduction in total dose and prevention of systemic toxicity and unusual side effects. The objective of the present investigation was to prepare & evaluate solid lipid nanoparticle (SLN) based topical gel of non-steroidal anti-inflammatory drug (NSAID) ketorolac tromethamine for the cure of arthritis which would attenuate the gastrointestinal related toxicities related with oral administration. SLNs had been prepared by means of low temperature solidification technique and characterize by means of particle measurement, analysis, FTIR spectroscopy, drug entrapment efficiency, SEM, in vitro In vitro release research were performed on Franz diffusion cell the usage of dialysis membrane in phosphate buffer solution of pH 7.4. The FTIR study indicates no predominant interaction of ketorolac tromethamine with different component ingredients and the Scanning Electron Microscope study revealed that the drug is molecularly dispersion into the lipid. The particle measurement determination confirms the particle distribution in the nanoparticle range (27% volume to 56% volume). In vitro drug release using the dialysis membrane as of the prepared SLNs is greatly higher than the pure drug. The stability of the formulation shows the stability of the formulation besides changing its performances on storage. Hence formulation of ketorolac tromethamine in SLN, enhances the dissolution price as properly as it will enhance the bioavailability of the drug which ought to the stabilized for the duration of storage.