Hemolytic Disease of Newborn due to Anti-c Antibodies - A Case Report

Hemolytic Disease of Newborn also called as erythroblastosis foetalis is caused by maternal alloimmunisation to blood group antigens expressed by fetal red blood cells. The Rh blood group is the main cause of Hemolytic Disease of Newborn. The Rh antibody Anti-D is most common to cause HDN. Due to prophylactic immunoglobulins, the isoimmunisation to D antigen is nowadays low. However other Rh red cell antigens remain a significant but uncommon cause of Hemolytic Disease of Newborn. Anti- c is the most important Rh antigen after D antigen to cause severe HDN. Therefore antibody screening should be performed for all pregnant women to reduce fetal or neonatal morbidity and mortality. We report a case of Hemolytic Disease of Newborn due to anti-c antibody in an infant of a Rh positive mother.