Study of Changes in Biochemical Parameter Cholesterol in Ovarian Tumors before and after Chemotherapy

Introduction: The cancer burden in India is given in gynaecological cancers occur in about 6.8% population. The lifetime risk of developing sporadic epithelial ovarian cancer is approximately 1.7% although patients with a familial predisposition have a much higher lifetime risk in the range of 10 to 40%. Methodology: Cholesterol in tissue and blood has consistently been found to have a prime role in the pathogenesis of coronary artery disease, but an association of cholesterol with cancers such as colorectal and breast cancer and leukemia has also been reported. The cholesterol content of cell membranes is tightly regulated, and this process of regulation involves the uptake of cholesterol-rich low-density lipoprotein (LDL). The present study designed with an aim to explore the changes in the biochemical profile Cholesterol of malignant and benign ovarian tumours pre therapy and post therapy. A case study control was conducted on 40 patients suffering from ovarian tumors (Benign and Malignant) who had reported to Rangaraya Medical College and hospital, Kakinada. Results: All stastical analysis was done using SPSS software and results were obtained The mean age of the patients were found to be 44.77 ? 11.66. Mean age of the patients with malignant tumors (n=29) was 47.7 to ? 9.26 years whereas for benign tumors (n=11) it was only 37? 4.34 years. hical committee clearance and informed the concent from the patients.