Retroperitoneal Liposarcoma: Clinicopathologic and Outcome Analysis

Introduction: Retroperitoneal liposarcoma (RPL), a rare adipose tissue malignant tumor, grows to a huge size before beinga clinically observed problem, its treatment options still under investigation. Tumor recurrence after resection and tumor growth management remain as anobstacle. Aim: The aim of this study is to correlatethe frequency and clinicopathological variablesof retroperitoneal liposarcoma to patients outcome. Materials and Methods: Retrospective analysis of surgical specimens of seven patientsand their clinical, surgical, treatment options and follow-up data were collected from medical documents. The specimens submitted toa private histopathology laboratory in Benghazi during the period from January 2018 to September 2019. Statistical analysis performed using IBM SPSS Statistics for Windows, version 22.Kaplan-Meier method used for survival analysis. Results: The patients` mean age was 63?9.7 years, nearly no gender predilection. Complete tumor resection wasperformed for all cases with adjoiningorgan resection in three cases.The mean tumors diameter was19.4?6.8 cm with clear resection margins.Histopathological examination showedwell differentiatedRPL (4 cases), dedifferentiated RPL (2 cases) and pleomorphic RPL (1 case) with grade I in 4 cases and grade II in (3 cases). There was no metastasis; (5 cases) were classified as stage I and (2 cases) as stage II. The mean follow-up period was 18?10.5 months and the median survival time 18 months (95%CI: 7.7-28). The better survival result was achieved in cases where only surgical resection of the tumorwas preformed (p-value: 0.008). The better survival result was also seen in cases with grade I (p-value of 0.01). Conclusion: Low grade tumor and complete tumor resection with negative margin were associated with better over-all survival result in RPL.