Non-Genomic Pathway Corticosteroid in HIV Patient with Pneumocystis Pneumonia - A Case Report

Steroid hormones are known to mediate physiological cell functions. Corticosteroid are known to have genomic and non-genomic mechanism. Non-genomic mechanism occurs faster than genomic pathway and referred to as extranuclear mechanism. This non-genomic mechanism exerts rapid inhibitory effects on human neutrophil degranulation at the cellular level. We present a 23-year-old patient with HIV and Pneumocystis pneumonia admitted at Wangaya Regional Hospital Denpasar who treated by high dose methylprednisolone to control the inflammation. High dose corticosteroid showed a non-genomic effect in this patient. Non-genomic effect has fast action to control inflammation. We have to control the inflammatory agent properly to achieve an optimal healing of patient. However, the use of high doses corticosteroids should carefully determine to avoid its side effects.