Meta-Analysis: A Higher Quality of Evidence in Clinical Research PyramidJournal: International Journal of Science and Research (IJSR) (Vol.9, No. 3)
Publication Date: 2020-03-05
Authors : Sonal Jain;
Page : 340-349
Keywords : meta-analysis; systematic review; evidence-based medicine;
Meta-analysis is a statistical tool used to systematically and quantitatively estimate the pooled effect of earlierindividual research studies to obtain conclusions about that research subject. The outcomes from a meta-analysis are more precise estimate of the effect of treatment or risk factor for disease, than any individual study. One of the potential advantages of conducting meta-analysis is to obtain an accurate and quantitative review of a large, complex and generally controversial topic in literature. Meticulously conducted meta-analyses are potential tools in evidence-based medicine. The small clinical trials (small sample size) might have inconclusive results on individual basis however, while combining these trials met-analysis increases the statistical power and thus more precise estimate of effect size.Moreover, meta-analysis is also useful for exploring sources of publication bias and quantifying between-study heterogeneity.
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