Evaluate the Effects of Silodosin and Solifenacin Combination with Silodosin Alone in Reducing DJ Stent Related Symptoms

BACKGROUND: Ureteral stents play a major role in a wide range of situations where urinary drainage is needed. The placement of stent produces variety of lower urinary tract symptoms . The study was aimed to Evaluate the effects of silodosin and solifenacin combination with silodosin alone in reducing DJ stent related symptoms (SRS). METHODS: A total of 150 patients who underwent DJ stenting and developed SRSwere randomized into 3 groups [Group A: silodosin (8mg OD) + solifenacin (10mg OD), Group B: silodosin (8mg OD) and group C: placebo]. IPSS, VAS for pain and QOL score were noted at 7th day. All groups received drugs for 14 days and IPSS, VAS for pain and QOL scores were noted at 21st day. RESULTS: Scores were similar in all groups at first week but group A and B had significant reduction in scores as compared to group C on 21stday . On statistical evaluation between A and B groups, score reduction was in favour of group A which was significant. CONCLUSION: Combination therapy with silodosin and solifenacin is effective for relieving stent related symptoms with improved QOL and less pain.