The Occurrence of Acalculous Cholecystitis in a Drug Hypersensitivity Reaction: A Case Report

Acalculous cholecystitis (AC) is defined as necro-inflammatory disease in gallbladder in the absence of gallstone which is caused by multifactorial. This case report aimed to show a severe systemic drug allergic reaction which attributed to AC. We reported a 23-year-old male who experienced acute systemic hypersensitivity reaction after 12 hours taking paracetamol. The patient showing generalized urticaria, epigastric and right upper quadrant of abdominal pain. Laboratory findings showed leukocytosis. Abdominal ultrasound showed the thickening of gallbladder wall, without the presence of gallstone and widening of bile duct. The patient was suspected of having vasculitis which complicated to gallbladder ischemia as the underlying cause of AC.