Correlation of Salivary Troponin I among High Risk Patients of Myocardial Infraction

Cardiovascular disease is the major complication of systemic illness like diabetes mellitus, hypertension, hypercholesterolemia and leading cause of death globally. . According to Framingham study, silent myocardial infraction is higher in diabetic patients than others. Salivaomics has emerged as a new branch of diagnostics paving way for early detection of diseases. The aim of the study is to quantify and compare the Salivary Troponin I among normal, high risk patients of myocardial infractions and post myocardial infract patients. Materials and Methods-The study included 30 individuals divided into three groups. Group I consisted of 10 normal participants, Group II consisted of 15 patients of chronic systemic illness like type 2 diabetes mellitus (T2DM) and hypertension and Group III consisted of 15 post myocardial infract patients (both T2DM and hypertension) who were under anticoagulant therapy at Mahatma Gandhi post graduate institute of dental science, Puducherry. Un stimulated saliva was collected and subjected to estimation of salivary troponin I using ELISA. . RESULT-The mean salivary troponin I levels in group I, II and III were 0.08pg/ml, 0.85pg/ml and 0.22pg/ml respectively. Correlation of salivary cardiac troponin I levels and random blood sugar was highly significant with a ‘p’ value of 0.001 in group II and 0.003 in group III. CONCLUSION-The salivary cardiac troponin I was increased in patients who are at high risk of developing cardiac events in the future (group II) when compared to the other groups. Serial salivary cardiac troponin I testing can reduce the morbidity and mortality in patients with chronic systemic illness.