DEVELOPEMENT, IN-VITRO EVALUATION AND OPTIMIZATION OF METOPROLOL SUCCINATE ORODISPERSIBLE TABLETS

The main objective of the present study is to design, evaluate and optimization of Metoprolol succinate orodispersible table (ODTs) with superdisintegrants. Orodispersible tablets disintegrate instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect. Various formulations of Metoprolol succinate tablets were prepared by direct compression method using different concentration of Superdisintegrants (Kollidon CL and croscarmellose sodium) 2.5% to 5 %. The blend of ingredients was evaluated for Angle of Repose (θ), Bulk Density, Carr’s Compressibility Index (CI) and Hausners Ratio. The Prepared tablets were evaluated for weight variation, thickness, hardness, friability, content uniformity, disintegration time and in vitro dissolution studies. All formulations were shows acceptable results for all the evaluation parameters and form the data formulation F4 was considered as an optimized formulation. Since it meets all standard requirements.