Histopathological Study of CNS Lesions - A Retrospective Study for 5 Years

Introduction: The human nervous system performs greatly varied and highly complex functions. CNS lesions consist of inflammatory, infectious, benign and malignant tumours. CNS tumours are not as frequent as tumours of other sites. Histologically malignant brain tumours carry a poor prognosis. Aims and objectives – histopathological study of various CNS lesions in to benign, malignant and infectious conditions. Methods: 5 yrs. retrospective study of CNS lesions, over the period march 2011 march 2015, in Narayana medical college, Nellore. A total 146 cases included in which 136 cases are neoplastic, 10 cases are inflammatory Results 5 yrs. under review (2011-2015) a total of 146 cases of CNS lesions were done histopathologically.136 (93.16 %) neoplastic cases, 10 (6.84 %) inflammatory cases. Among 10 CNS infections cases, fungal infections were of 5 (50 %) cases, 4 cases (40 %) were of granulomatous (Koch's) aetiology.1 (10 %) case of Toxoplasmosis. Of the 136 cases of CNS neoplasms, 96 (70.58 %) cases were of benign aetiology, and remaining 40 (28.42 %) cases were malignant tumours, in which 30 cases of primary CNS malignant tumours were noted, Remaining 10 were metastatic tumours. Conclusion – Central Nervous System lesions include benign and malignant neoplasms and infections. Glial tumours are the most common lesions. Most of the lesions are of Grade I neoplasms.