Postpartum Rat Systolic Blood Pressure with Gynura Procumbens Leaf Extract

Introduction: Complications of postpartum hypertension can lead to retinal failure, kidney failure, stroke, pulmonary edema, damage to blood vessels in the heart, cerebrovascular sequela to cause death. The purpose of this study was to find out the picture of blood pressure of Wistar mice after the administration of Gynura procumbens extract. Material and Methode: This is a randomized controlled trial. The study subjects consisted of 20 female Wistar mice after giving birth which was divided into control groups and treatment groups. Induction of hypertension with a diet high in salt (NaCl 8 %, 3ml/hr) and prednisone 3 gr/kgBB was given for 14 days. Negative control group intervention using aquades 3ml/hr, positive control group intervention using nifedipine 3 mg/kg bb, and intervention group using Gynura procumbens extract 10 mg/kg bb and nifedipine 3 mg/kg bb. Intervention is carried out for 14 days. Result: The results showed that there was a significant increase in systolic blood pressure after the induction of hypertension and there was a greater decrease in systolic blood pressure values after intervention in the intervention group when compared to the positive control group, namely systolic blood pressure. Conclusion: decreased systolic blood pressure after administration of Gynura procumbens and nifedipine was greater than that given nifedipine alone. Gynura procumbens can lower systolic blood pressure values in postpartum Wistar mice.