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Neurology and COVID-19 in Pediatrics

Journal: International Journal of Science and Research (IJSR) (Vol.9, No. 12)

Publication Date:

Authors : ;

Page : 1088-1090

Keywords : Corona virus; SARS-CoV-2; COVID-19; ACE2 tissue distribution; host−virus interaction; spike protein;

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The recent outbreak of corona virus infectious disease 2019 (COVID- 19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of the ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome corona virus (SARSCoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host−virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.

Last modified: 2021-06-28 17:17:01