Application of Tranexamic Acid in Total Knee Replacement Surgeries

Total knee replacement surgeries are associated with perioperative blood cell transfusions and a higher rate of postoperative morbidity and mortality. Perioperative antifibrinolytic therapy is recommended to reduce blood loss. This study was conducted on a total of 30 subjects randomly divided into two groups of 15 patients each. The first group (Group T) received Tranexamic acid (15 mg/kg of body weight mixed in 100 ml normal saline). The second group (Group P) received a bolus of an equivalent volume of placebo (normal saline), 10 minutes before the deflation of the pneumatic tourniquet respectively. Our study showed that Group P lost almost five times more blood during the recovery phase and twice the volume of Group T in the surgical ward. Based on the results of the present study, we concluded that use of Tranexamic Acid significantly reduces blood loss caused by TKR performed with a tourniquet