Uncommon Presentation of Primary Oral Syphilis: Multiple Herpetiform Chancres in HIV-Negative Patient

Primary Syphilis is characterized by the development of a painless chancre at the site of inoculation associated with a satellite lymphadenopathy. Multiple syphilis chancres (MSC) occur most frequently in HIV patients. This article describes a rare case of a young male HIV negative patient with multiple herpetiform syphilitic chancres (MHSC) on his lower lip. The aim of this case report was to emphasize the features of atypical presentation of primary syphilis and to report, for our knowledge, the first case of MHSC of the oral cavity reported in the literature.