Evaluation of Titanium Ions Levels in Blood in Patients with Endosseous Titanium Dental Implants using Inductively Coupled Plasma Mass Spectrometry - A Retrospective Study

The present study investigates the amount of titanium (Ti) released in blood of patients after implant and crown placement in a period ranging from 1 to 5 years. Over the years of a functional implant, it has been conceptualized that titanium di oxide layer can be destroyed during the micro-mechanical movement between the implant and bone and cause corrosion which leaks out small metallic particles or ions to leak into living tissues. This leak of metal ions may happen in relatively large concentrations into adjacent tissues and these can be present as nanoparticle debris or as organometallic complexes (bound to tissue proteins). In this study, the quantity of Ti present in the blood of patients who received implants, was measured using a wide range of atomic analytical techniques such as Inductively Coupled plasma mass spectrometer (ICP-MS) which detects the lowest limit of Titanium levels in blood.