Hepatomodulation of Cigarette Smoke Toxicity by Terminalia arjuna Stem Bark in Rats

The aim of the present study was to analyze the effect of alcoholic extract of Terminalia arjuna (arjuna) on histological changes in liver of cigarette smoke exposed albino rats. The rats were grouped into three sets- control (I) and two experimental sets (II and III) consisting five rats each. Rats of set (I) was unexposed to cigarette smoke, set (II) was exposed to cigarette smoke for one hour/day for 30 days and set (III) was exposed to cigarette smoke with oral administration of alcoholic extract of Terminalia arjuna for 30 days. Histology of liver tissue in cigarette smoke exposed rats showed varying pattern of histological alterations such as hepatocytes degeneration, hepatocytes necrosis, centrilobular necrosis, expanded sinusoidal spaces and cellular debris. After oral administration of alcoholic extract of Terminalia arjuna, all of such histopathological alterations have been mitigated in comparison to cigarette smoke exposed rats.