A Comparative Study of Effects of Intravenous Nitroglycerine and Esmolol on Hemodynamic Response Following Tracheal Extubation

Introduction One of the main concerns for the anesthesiologist is to prevent hypertension, tachycardia and arrhythmias during extubation, and to ensure an awake patient with fully airway control and stable hemodynamics. Our aim was to compare the effects of intravenous Nitroglycerine and intravenous Esmolol on hemodynamic response following tracheal extubation in patients posted for major surgical procedure and to study its safety and side effects if any associated with it. Materials& Methods The patients were randomly divided into two groups and would receive the drugs blindly. GROUP A (Esmolol group) (n=50) received intravenous Esmolol (1mg/kg body wt) GROUP B (NTG group) (n=50) received intravenous Nitroglycerin (1mcg/kg body weight) Observations Administration of intravenous nitroglycerin and intravenous esmolol prior to extubation in ASA grade I patients are effective, practical, easy and relatively safe method of protecting patient from the hypertension and complications related with hypertension without much affecting heart rate during extubation. Conclusion Intravenous Esmolol has as much haemodynamic stability as intravenous Nitroglycerine during extubation period and both attenuates extubation response without any adverse effect and complications.