The Analysis of Obesogen Phthalates and Genetical Mutation on Teens in Kediri CityJournal: International Journal of Science and Research (IJSR) (Vol.7, No. 10)
Publication Date: 2018-10-05
Authors : Sukojo Suwandani; Edi Widjajanto; M. Rasjad Indra; Sri Andarini;
Page : 22-29
Keywords : Obesity; Obesogen; Tempe; Isoflavones;
The obesity is an abnormality or disease that with excessive accumulation of body fat tissue. The occurrence of Obesity is caused by many factors, including diet, lifestyle, culture, genetics, and the environment. Fast food, labor-saving equipment, and inactive work habits can make body fat. Obesogen is known as an important element of the cause of obesity. Obesogen is a substance present in the environment, due to the use of certain substances in the processing of foodstuffs and other necessities in meeting human needs, which affects the disturbances of the hormonal system to genetic disorders. There is a difference in levels of obese to phthalates in obese adolescents and not obese. Obesogen phthalate cause obesity in adolescent. The environment influences obesity through genetic disorders through epigenetic DNA methylation. In this study DNA methylation did not occur, but DNA mutations. The conclusion of this study is 1) All obesity and non obesity samples are exposed to phthalate low molecule and high molecule, 2) Phthalate exposure is relatively no different, 3) The junior high school children of Kediri had phthalate molecule low and high phthalate molecule, where the amount of exposure is relatively the same for both obese and non obesity children, men, and women, 4) Genetic changes occur in the form of mutations (not epigenetic methylation), where adolescent obese is obtained 2x from non-obese.
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