The Regenerative Role of Vitamins B1, B6, B12 in Treatment of Peripheral Neuropathy

The peripheral neuropathy is one of the common complications of various types of diseases, trauma and vitamins deficiency. Till now the C. N. S has no ability to regeneration, while peripheral nervous systems can be regenerate following trauma or disease, So many medication had been used to relieve neurological pain or to regenerate the peripheral nerve. One of the most commonly drugs used is vitamins B. However which one of vitamins B is more effective in regeneration of nerve damage is still obscure. Aim of study Study the effect of various types of vitamins B on regeneration of damage nerve through morphometrical and histological study. Materials and methods 60 albino rats had been conducted in this study. Each rat exposed to sciatic crush injury. Those animals had been divided into 4 groups, group A consider as a control experimental group, group B received vitamin B1, group C received vitamin B6, while the last group treated with vitamin B12. Each rat examined macroscopically and histologically. Result The results obtained illustrated regeneration of all groups treated with various types of Vitamins B. However the degree of regeneration had been differed according to the type of vitamin B. Vitamin B12 treated animals revealed best regeneration, followed by B1 treated animals and the least effect could be observed in animals treated with B6. Conclusion This variable response to regenerative role of vitamins B could be attributed to the mechanism of action of each types of vitamins B.