Systemic Drug Delivery via Oral Mucosa - A Review

Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods and also enhances drug bioavailability because the mucosal surfaces are usually rich in blood supply, providing the means for rapid drug transport to the systemic circulation and avoiding, in most cases, degradation by first-pass hepatic metabolism. This article aims at discussing the various drugs and the methods of delivery used to administer them through the oral mucosa.