Histological and Ultrastructural Studies on the Kidney of Male Albino Mice after Treatment with Single Dose of LD50 Naja Naja Snake Venom

The common sign of snake envenomation is Nephrotixicity or renal injury that is dependent on quality and quantity of venom. To clarify the effect of intraperitoneal (i. p. ) injection of LD50 dose of Naja naja snake venom on the renal tissues of albino mice after 3 and 24 hr from envenoming respectively. The mice were divided into 3 groups, the first group served as a control group, while the other groups II and III were treated with the snake venom (0.055 g/g body weight i. p) and sacrificed by decapitation after3 and 24 hours of the snake venom injection respectively. The kidney was isolated and histological and ultrastructural sections were prepared. Intraperitoneal LD50 for Naja naja snake cobra was determined in rats to be equal to 0.055 g/g body weight. Histopathologicalchanges in kidney tissues after 3 hr from injection were congested of some glomeruli, some glomeruli atrophied and vacuoles in renal tubular. Histopathological changes in kidney tissues after 24 hr from injection were degenerative changes on the renal cortex, hyalinizati of some renal tubule. Besides that observation of the inflammatory cell infilterations. Ultrastructural changes in kidney tissues after 3 hr from injection were condensation of nuclear chromatin endoplasmic reticulum were fragmented in some position, swollen and variable sizes mitochondria. Ultrastructural changes in Kidney tissues after 3 hr from injection were necrotic of some endothelial cells and necrotic of some podocyt. The injection of LD50 dose of Naja naja snake venomin rats caninduce kidney damage and nephrotixicity or renal injury in albino mice.