Prediction of Insulin Resistance using Modified Single Point Insulin Sensitivity Estimator and Determination of Atherogenic Index of Plasmain Asthmatic Patients

Background Chronic obstructive pulmonary disease including asthma is the fourth leading cause of death world over. About 235 million people currently suffering from asthma, which is abnormal inflammatory response of the lungs characterized by airflow limitation, airflow obstruction and bronchospasm. Metabolic syndrome is asyndrome that involves at least one of the three disorders of dyslipidemia, insulin rsistance, obesity and/or hypertension. There are close links between asthma and metabolic syndrome. Asthma and dyslipidemia are epidemiological linked, similar relationships are also observed with other marker of the metabolic syndrome such as increase prevalence of coronary heart disease, stroke and diabetes. The purpose of this study is to describe the link between metabolic syndrome and asthma using easy and affordable tools for the prediction of disease complication. Methodology A total of 95 individuals, 50 (53 %) were asthmatic patients and 45 (47 %) were healthy controls were enrolled in this prospective case control study during the period from January to April, 2017. Blood specimens were collected from each individual in heparin anticoagulated container after fasting period of 12 hours, separated within 2 hours stored at 4oC and analyzed within 2 days. Estimation of total cholesterol, TG, LDL-C, and HDL-C were performedusing (Cobas c311 chemistry analyzer). Calculation of atherogenic index and calculation for insulin resistance was done using SPISE equation. Results The mean of atherogenic index of plasma (AIP) for subjects and control groups were 0.45 0.18 and.0.17 0.11 respectively (P value 0.000**) The mean of insulin resistance (IR) for the patients and controls groups were 6.3 0.5 and 7.2 0.4 respectively (P value0.000**). Conclusion Our study showed that Asthmatic patients have a higher rate of developing cardiovascular disease and insulin resistance than normal subjects.