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Angiogenic Biomarkers of Dysfunctional Uterine Bleeding
Journal: International Journal of Science and Research (IJSR) (Vol.6, No. 5)Publication Date: 2017-05-05
Authors : Ketki K; Shailesh Kumar;
Page : 2127-2132
Keywords : Angiogenesis; Dysfunctional uterine bleeding DUB; Hypoxia inducible factor 1 alpha HIF-1; Matrix metalloproteinase -9 MMP-9; Copper; Vascular endothelial growth factor VEGF;
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Abstract
Disturbed endometrial angiogenesis plays a role in the mechanism of Dysfunctional uterine bleeding (DUB). Under hypoxic conditions, Hypoxia inducible factor 1 alpha (HIF-1) rapidly accumulates and activates angiogenic growth factors, receptors and extracellular proteases such as matrix metalloproteinases (MMPs) like MMP-9. Copper influences the production of number of angiogenic factors including HIF-1.
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