Correlation between Fasting Blood Glucose and HbA1c in First Degree Relatives of Sudanese Diabetic Patients as a Predictor of Type 2 Diabetes Mellitus

Background About 415 million people has diabetes worldwide, with type 2 diabetes mellitus (DM) making up about 90 % of the cases. Glycated hemoglobin is a measure of the risk for the development of complication of diabetes. This study is aim to compare between levels of fasting blood glucose with HbA1c in first degree relatives (FDR) of patients with type 2 diabetes mellitus and healthy non diabetic subjects as predictor to have diabetes type 2 in future. Material and method This case control study contain 35 patients with type 2 DM, 35 FDR and 35 apparently healthy non diabetic control subjects. Fasting blood glucose were assayed using glucose oxidase method, HbA1c were assayed using immunoassay technique. Results The mean age was 29 years for relatives and 25 years for controls, the mean and standard deviation of fasting blood glucose in FDR and control was (84.89 mg/dl 17.01, and 84.51 mg/dl 13.04 respectively) and for HbA1c was (6.14 % 1.06, 5.86 % 0.699 respectively), this study show no significant difference in fasting blood glucose and HbA1c between FDR and control subjects (p value 0.919, 0.189 respectively). Conclusion Fasting blood glucose and HbA1c may not be used as a predictor of diabetes in first degree relatives of diabetic patients.