Salivary Matrix Metalloproteinase (MMP-8) in Relation to Periodontal Health Status among a Group of Patients with Acquired Coronary Heart Disease

Background Many studies have investigated relation between oral health and periodontal diseases with coronary heart diseases. Although the evidence linking periodontal diseases with coronary heart diseases is not yet conclusive, recent evidence raised the support to the role of periodontal diseases in the initiation and progression of coronary heart disease. Aim of study This study was conducted to measure salivary matrix metalloproteinase - 8, in relation to periodontal pocket depth and clinical attachment loss, among a group of patients with coronary heart disease in comparison with control group. Materials and methods Sixty subjects, aged 45-50 years old, they were seeking treatment for chest pain. They were divided into study group (30 patient), were diagnosed to be a candidates percutaneous coronary interventions (PCI) group, and a control group (30 subject), who scored a negative result in the tread mill test, and was no need for a cardiac angiography. Probing pocket depth (PPD) and clinical attachment level (CAL), were measured according to Lindhe et al. (1999). Un stimulated saliva was collected from all subjects, according to Navazesh and Kumar, (2008), to analyses MMP-8. Result A high mean value of CAL for the PCI group than the control group with statistically highly significant difference. High mean value of PPD for the PCI group than the control group, a statistically, non-significant was found. Salivary MMP-8 level was less in the PCI group than in the control group, with statistically no significant difference between groups. A positive correlation between MMP-8 with PPD. and CAL in the PCI groups. However, statistically non-significant (Pgreater than0.05). Conclusion Although periodontal diseases revealed higher percentage of occurrence among a group of patients with coronary heart disease, salivary MMP-8 were found to have little effects on the periodontal status of the study group. Salivary Matrix Metalloproteinase (MMP-8), Periodontal pocket depth, Acquired coronary heart disease.