Nephroprotective Effect of Arumuga Chendooram in Experimental Hypothyroid Rats

The functioning of the kidneys is efficiently monitored and regulated by hormonal feedback mechanisms involving the hypothalamus. One of the major functions of the Urinary system is the process of excretion. Excretion is the process of eliminating, from an organism, waste products of metabolism and other materials that are of no use. The primary function of the kidneys is to maintain a stable internal environment (homeostasis) for optimal cell and tissue metabolism. They do this by separating urea, mineral salts, toxins, and other waste products from the blood. They also do the job of conserving water, salts, and electrolytes. In the present study, prominent increase in creatinine, urea, sodium and decrease in potassium concentrations are suggested as a sign of significant functional impairment of kidney in methimazole treated group. Administration of Arumuga chendooram along with methimazole treated in the curative groups helped in restoring the creatinine, urea, sodium and potassium concentration to near normal levels. This probably points towards the nephroprotective property of Arumuga chendooram.