A Large Twisted Mesenteric Gist-Presenting as an Acute Abdomen - A Rare Case Report

Gastrointestinal stromal tumors are the most common mesenchymal tumors of the digestive tract, and can arise from any part of the GI tract, frequently found in the stomach ~ 50 %, followed by small intestine (25 %) small intestine [1], however, very rarely, may also occur in extra intestinal locations such as omentum, mesentery, pelvis or retroperitoneum [2]. GISTs present as a wide spectrum of disease with certain clinicopathological features such as tumor size, mitotic activity and site of origin, determining the aggressiveness of the disease. While surgery is the mainstay of the treatment in localized GISTs, achieving cure rate in 45-60 % cases [3], Imatinib mesylate, a tyrosine kinase inhibitor (TKI) is an important drug for targeted therapy in locally advanced and metastatic GISTs and also in specific genotypes of GISTs.