Effect of Bee Venom and Other Natural Product (Dates) Onlung Cancer: Invitro Trial

Bee venom has special pharmacological activity for its enzymes and peptides containment. Melittin is the bee venoms main constituent. The present work aimed to in vitro estimation of the anti-cancer potentials of bee venom (BV) in addition to evaluation of the synergetic potential of dates extract to bee venom against lung cancer (A549). BV showed a higher toxicity toA549 cells accompanied with synergetic activity of its toxicity in combination with daters extracts where the IC50 was arranged in the order of BVgreater than Mixgreater than Dates compared with Doxorubicin as a positive control. Data revealed that BV/dates extract has a synergetic potential to BV that was accompanied with Anticancer activity via up/down regulation of pro and anti apoptotic genes compared with control, caspase-3, Bcl-2 andpro-apoptotic gene (p53). Cell cycle analysis revealed that bee venom, dates and their mix induced pre G1 apoptosis and cell cycle arrest at G2/M phase.