Effect of Krill Oil Application on Wound Healing in Male Rats

Wound healing is an active process of communication between cells, matrix, and various growth factors. Krill oil is a rarely used substance having medicinal properties with wound healing, as anti-inflammatory, antioxidant and renewal of tissues. The current study aimed to study the role of krill oil in the wounded skin healing and repair. Skin wound incisions were performed in the right thigh area of thirty mature male rats (aged 10 weeks and weighing 1654.5 g). Wounded skin rats were assigned into two equal groups. Wounded areas were daily treated with a local application of 1 L of normal saline (control group) and 1 L of krill oil (treatment group). After 1, 5, and 10 days, five rats from each group were sacrificed and tissue samples from the wounded areas were obtained for histopathological examination. Histopathological examination revealed time-dependent successive acceleration of wound healing in the krill oil-treated rats compared with that of control rats throughout the experimental period. Improvements were observed with regard to the level of epithelialization, infiltration of inflammatory cells, and constriction of the wound area. In conclusion, local application of krill oil has therapeutic efficiency to accelerate wound healing.