Prevalence, Clinical and Histopathological features of Microscopic Colitis in Some Egyptian Patients with Diarrhea-Predominant Irritable Bowel Syndrome

Background Irritable bowel syndrome (IBS) is a common functional gut disorder where its diagnosis can be challenging and uncertain due to presence of many organic diseases that can mimic IBS and one of the commnest these disorders is MC. Patients and methods 120 patient with diarrhea predominant irritable bowel syndrome (IBS-D) were subjected to full history and physical examination. Colonscopy with multiple biopsies were done for all patients and refered for histopathological examination. Results Distinct colonscopic findings were found in 19 patient were excluded.8.9 % of patients were diagnosed with lymphocytic colitis (LC) and 1.9 % of cases with collagenous colitis (CC) with a mean age of 49 years and women are affected with microscopic colitis (MC) more than men. Nocturnal diarrhea ocurrs in 72.7 % of cases with a mean frequency 4 times per day. Conclusions Clinical presentation alone is not sufficient in differentaition between MC from IBS-D. The hallmark of diagnosis is histopathological diagnosis. Colonscope with multiple biopsies is recommended for all patients with IBS-D.