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Chronic Myeloid Leukemia - An Overview

Journal: International Journal of Science and Research (IJSR) (Vol.3, No. 1)

Publication Date:

Authors : ; ; ;

Page : 129-132

Keywords : Chronic Myeloid Leukemia;

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CML is a myeloproliferative disorder characterized by a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), a balanced translocation, involving a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11. The molecular consequence of this translocation is the generation of a BCR-ABL fusion oncogene, which translates into Bcr-Abl oncoprotein with increased tyrosine kinase activity. (1)

Last modified: 2021-06-30 20:48:16